Other characters
- Victor Frankenstein
Charlie TahanEnglish - Mrs. Frankenstein / Weird Girl / Gym Teacher
Catherine O'HaraEnglish - Mr. Frankenstein / Mr. Burgemeister / Nassor
Martin ShortEnglish - Mr. Rzykruski
Martin LandauEnglish - Edgar 'E' Gore
Atticus ShafferEnglish - Elsa Van Helsing
Winona RyderEnglish - Bob
Robert CapronEnglish - Toshiaki
James Hiroyuki LiaoEnglish - Bob's Mom
Conchata FerrellEnglish - New Holland Towns Folk
Tom KennyEnglish - Sparky (voice) (uncredited)
Frank WelkerEnglish - Persephone / Shelly / Were-Rat / Colossus / Mr. Whiskers / Driver (voice) (uncredited)
Dee Bradley BakerEnglish - Giant Sea Monkeys (voice) (uncredited)
Jeff BennettEnglish - Additional Voices
Jon DonahueEnglish