Saika Kuozaki, a powerful witch, is the only one capable of stopping mysterious entities that threaten to destroy the world every 300 hours. When she is gravely injured, she transfers her powers and her body to Mushiki Kuga, an ordinary high school boy who stumbles upon her. Although Mushiki now possesses her abilities, he struggles to control them. To protect the world, he must enroll in a mage academy disguised as Saika, all while keeping his true identity a secret.